An arthritis drug — Tofacitinib — developed by US biopharmaceutical Pfizer has shown to be effective in reducing the risk of death or respiratory failure in hospitalized adult patients with Covid-19 pneumonia who were not on ventilation, according to a study.
Tofacitinib belongs to a class of drugs called Janus kinase (JAK) inhibitors. It is approved in the US to treat conditions including rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
The efficacy of Tofacitinib was tested on 289 patients hospitalized with severe Covid across 15 locations in Brazil. Half of these patients received 10 mg twice daily plus standard of care which includes glucocorticoids, while the other half were prescribed placebo twice daily plus standard of care for up to 14 days.
The results published in the New England Journal of Medicine showed that after 28 days, tofacitinib lowered the death or respiratory failure by 63 percent. Among patients on tofacitinib, only 18.1 percent had the incidence of death or respiratory failure compared to placebo (29 percent).
Deaths in the tofacitinib group occurred in 2.8 percent of patients and in 5.5 percent of those in the placebo group.
Serious side effects occurred in 14.1 percent in the tofacitinib group and in 12 percent in the placebo group.
“We are encouraged by the initial findings of our randomized trial of tofacitinib in patients hospitalized with Covid-19 pneumonia,” said Otavio Berwanger, Director of the Academic Research Organisation, Hospital Israelita Albert Einstein, which coordinated the trial in collaboration with Pfizer.
“These results provide new information which indicates that the use of tofacitinib when added to standard of care, which includes glucocorticoids, may further reduce the risk of death or respiratory failure in this patient population,” Berwanger added.
However, it is important to note that tofacitinib has not been approved or authorized for use by any regulatory authority worldwide for the treatment of Covid-19 and tofacitinib should not be used in patients with an active serious infection, the researchers said.
