why our hairs turn grey

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melanocyte stem cells that may be responsible for grey and loss of hair colour

Stem cells which get stuck as people age may be the reason why our hairs turn grey, US scientists have found. The team from New York University (NYU)- Lagone, in a mice study, showed that certain stem cells have a unique ability to move between growth compartments in hair follicles. However, as people age, it gets and thus lose their ability to mature and maintain hair colour. The study, published in the journal Nature, focused on cells in the skin of mice, which in humans are called melanocyte stem cells, or McSCs.

“Our study adds to our basic understanding of how melanocyte stem cells work to colour hair,” said study lead investigator Qi Sun, a postdoctoral fellow at NYU Langone Health. “It is the loss of chameleon-like function in melanocyte stem cells that may be responsible for grey and loss of hair colour. These findings suggest that melanocyte stem cell motility and reversible differentiation are key to keeping hair healthy and coloured,” added said Mayumi Ito, Professor at NYU Langone Health. In the latest experiments in mice whose hair was physically aged by plucking and forced regrowth, the number of hair follicles with McSCs lodged in the follicle bulge increased from 15 per cent before plucking to nearly half after forced ageing. These cells remained incapable of regenerating or maturing into pigment-producing melanocytes.

The stuck McSCs, the researchers found, ceased their regenerative behaviour as they were no longer exposed and hence their ability to produce pigment in new hair follicles, which continued to grow. By contrast, other McSCs that continued to move back and forth between the follicle bulge and hair germ retained their ability to regenerate as McSCs, mature into melanocytes, and produce pigment over the entire study period of two years.
Ito said the team has plans to investigate means of restoring the motility of McSCs or of physically moving them back to their germ compartment, where they can produce pigment.

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ChatGPT fails when it comes to accounting, finds major study

AI chatbot ChatGPT is still no match for humans when it comes to accounting and while it is a game changer in several fields, the researchers say the AI still has work to do in the realm of accounting.

Microsoft-backed OpenAI has launched its newest AI chatbot product, GPT-4 which uses machine learning to generate natural language text, passed the bar exam with a score in the 90th percentile, passed 13 of 15 advanced placement (AP) exams and got nearly perfect score on the GRE Verbal test.

“It’s not perfect; you’re not going to be using it for everything,” said Jessica Wood, currently a freshman at Brigham Young University (BYU) in the US. “Trying to learn solely by using ChatGPT is a fool’s errand.”

Researchers at BYU and 186 other universities wanted to know how OpenAI’s tech would fare on accounting exams. They put the original version, ChatGPT, to the test.

“We’re trying to focus on what we can do with this technology now that we couldn’t do before to improve the teaching process for faculty and the learning process for students. Testing it out was eye-opening,” said lead study author David Wood, a BYU professor of accounting.

Although ChatGPT’s performance was impressive, the students performed better.

Students scored an overall average of 76.7 percent, compared to ChatGPT’s score of 47.4 percent.

On 11.3 percent of questions, ChatGPT scored higher than the student average, doing particularly well on AIS and auditing.

But the AI bot did worse on tax, financial, and managerial assessments, possibly because ChatGPT struggled with the mathematical processes required for the latter type, said the study published in the journal Issues in Accounting Education.

When it came to question type, ChatGPT did better on true/false questions and multiple-choice questions but struggled with short-answer questions.

In general, higher-order questions were harder for ChatGPT to answer.

“ChatGPT doesn’t always recognize when it is doing math and makes nonsensical errors such as adding two numbers in a subtraction problem or dividing numbers incorrectly,” the study found.

ChatGPT often provides explanations for its answers, even if they are incorrect. Other times, ChatGPT’s descriptions are accurate, but it will then proceed to select the wrong multiple-choice answer.

“ChatGPT sometimes makes up facts. For example, when providing a reference, it generates a real-looking reference that is completely fabricated. The work and sometimes the authors do not even exist,” the findings showed.

That said, authors fully expect GPT-4 to improve exponentially on the accounting questions posed in their study.

“Revolutionizing Our World: How Artificial Intelligence is Helping Humans”

Artificial Intelligence (AI) has been a topic of discussion for many years, but in recent times it has become increasingly relevant as technology continues to evolve at an exponential rate. AI involves creating computer systems that are capable of performing tasks that traditionally require human intelligence, such as making decisions, recognizing speech, and translating languages. With its potential to improve efficiency and productivity across a wide range of industries, AI is set to revolutionize the way we live and work.

One of the most significant ways in which AI will help humans is by improving healthcare. AI-powered technologies can be used to identify and diagnose diseases faster and more accurately than humans, leading to better patient outcomes. For example, AI can analyze large amounts of medical data to identify patterns that could indicate the early onset of a disease, allowing doctors to intervene before it becomes a more serious issue. AI can also be used to create personalized treatment plans for patients based on their medical history and current condition, leading to more effective treatments.

"revolutionizing our world: how artificial intelligence is helping humans"

Another area where AI can have a significant impact is in the workplace. AI-powered machines and robots can take over repetitive and mundane tasks, freeing up human workers to focus on more complex and creative work. This not only increases productivity but also reduces the risk of work-related injuries and fatigue. Furthermore, AI can be used to optimize workflows and supply chains, leading to cost savings and improved efficiency.

In the field of transportation, AI-powered systems are already being used to make our roads safer. Self-driving cars and trucks can reduce the risk of accidents caused by human error, leading to fewer injuries and fatalities. AI can also be used to optimize traffic flow, reducing congestion and improving travel times.

In the world of entertainment, AI can be used to create more personalized experiences for consumers. For example, AI-powered recommendation engines can analyze user data to suggest movies, TV shows, and music that the user is likely to enjoy. This can lead to more engagement and loyalty from consumers, ultimately leading to increased revenue for content creators.

Finally, AI can be used to address some of the most pressing global challenges, such as climate change and poverty. For example, AI can be used to optimize energy consumption, leading to reduced carbon emissions. AI can also be used to identify areas where poverty is most prevalent, allowing governments and non-profit organizations to target their resources more effectively.

In conclusion, AI is set to transform the way we live and work in countless ways. By automating repetitive tasks, improving healthcare, optimizing transportation, and addressing global challenges, AI has the potential to make our lives easier, safer, and more fulfilling. As with any new technology, there are also risks and challenges associated with AI, but with careful management, these can be minimized. Ultimately, AI is a powerful tool that has the potential to improve the quality of life for millions of people around the world.

Google CEO Sundar Pichai’s 2022 Pay Soars to $226 Million Despite Company Layoffs

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Amid cost-cutting measures and job cuts at Google’s parent company Alphabet, its CEO Sundar Pichai received a total compensation of almost $226 million in 2022, mostly from stock awards. However, Pichai’s salary has remained the same for the past three years at $2 million.

On January 20, Google’s CEO confirmed the layoff of over 12,000 employees worldwide, amounting to more than 6% of the total workforce. In addition to layoffs, Google is reducing perks like free snacks and workout classes for employees.

The company has also stopped spending on personal equipment and informed employees that fewer of them will be promoted to senior positions this year. Google India also terminated more than 400 employees, and some affected workers shared their experiences on LinkedIn.

Creators on social media are earn 41,000/- a month

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Digital content creators on social media

Over 10 lakh Indian digital content creators on social media are earning 41,000\- a month each in the next three years, a report revealed on Friday. The annualized growth rate for India is over 115 percent for individual creators as compared to the global growth rate of 18 percent, according to the report by creator economy startup Animeta on ‘International Creators Day’. In three years, 10 lakh creators in India would have at least 100,000 subscribers/followers, growing at 37 percent at an annualized level, which will allow them to have a steady digital income at par with a decent-paying full-time job.

Currently, more than 3,500 brands and over 5,000 creator partners in India are actively engaged in digital creator-driven branded content. Over 20,000 branded content pieces have generated over half a billion engagements. “All signs are pointing towards the trend that the Indian creator economy will become the most significant growth contributor to the global creator economy in the next couple of years,” said Devdatta Potnis, CEO, of Animeta.

Singapore-based Animeta focuses on creating and nurturing digital creators by helping them grow their communities and maximize their earnings across multiple social media platforms and customized brand solutions. “Sponsored content space is getting more organized and performance marketing metrics usage are on the rise in a cost-conscious market, where the rules of business and marketing are getting rewritten overnight,” said Krishna Desai, CPO and Data Scientist, Animeta.

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ISRO moves GSAT-12 satellite to graveyard orbit

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The Indian space agency has successfully disposed of the communication satellite GSAT-12 in a post-mission disposal (PMD) operation last month.

According to the Indian Space Research Organisation (ISRO), the post-mission disposal operation of GSAT-12 was completed on March 23, 2023.

GSAT-12 is the twenty-third Geosynchronous Earth Orbital (GEO) satellite to undergo PMD before decommissioning, ISRO said.

The satellite carrying 12 extended C band transponders was launched on July 15, 2011. It was located at 83 degrees E longitude till March 2021. After the launch of its replacement satellite CMS-01 in 2020, it was later relocated to 47.96 degrees E longitude. The satellite served for more than a decade.

The GEO regime is one of the most populated and highly utilized regions. Internationally accepted space debris mitigation guidelines by the UN and IADC recommend disposing of an object away from the GEO region at its end-of-life.

The recommended practice is to re-orbit the object to a nearly circular “graveyard” orbit sufficiently above the GEO region so that the orbit would not decay back into the GEO-protected zone under the influence of perturbation forces, such as non-uniformity of Earth’s shape, Sun’s Moon’s gravity, solar radiation pressure, etc., within another 100 years, ISRO said.

Hence, the final disposal orbit must meet specific criteria on the minimum raise in perigee altitude depending on the object’s reflectivity, mass, shape, and size. The graveyard orbit also needs to be nearly circular (very low orbital eccentricity, less than or equal to 0.003).

According to ISRO, for GSAT-12, the required minimum raise in perigee altitude was estimated to be 261 km. As a result of meticulous operations management by the Master Control Facility (MCF), the available fuel of GSAT-12 was more than sufficient to meet this goal.

A series of seven maneuvers were carried out to raise the orbit above the GEO altitude of 35,786 km. The first maneuver on March 16, 2023, was a shorter burn to circularize the orbit, followed by another six burns, typically of 150 seconds duration.

After completing the seventh burn on March 19, the satellite reached a super-synchronous circular orbit of nearly 400 km above the GEO altitude.

Space Debris Mitigation guidelines also recommend passivation/removing all energy sources, fluidic and electrical, to minimize the risk of any post-mission accidental break-up.

Four inclination-changing maneuvers of GSAT-12 were carried out during March 20-22 to spend the remaining propellant. On March 23, the final passivation maneuver was carried out to vent out the remaining fuel by firing the oppositely mounted thrusters, canceling the net thrust without affecting the orbit, the Indian space agency said.

As part of electrical passivation, all rotating mechanisms such as the momentum wheels, reaction wheels, and gyros were turned off, batteries were disconnected from the solar panels and discharged. Finally, the transmitters were switched off to avoid any potential RF interference. The passivation activities were completed on March 23, 2023.

All operations were conducted by MCF, Hassan, in coordination with U R Rao Satellite Centre, SATCOM Programme Office, and IS4OM (ISRO System for Safe and Sustainable Space Operations Management).

Google Considering Using Generative AI in Its Advertising Business

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According to recent reports, Google is planning to introduce generative artificial intelligence into its advertising business, which could allow the tech giant to create more complex ads. This technology will likely be incorporated into Google’s Performance Max program, which already uses algorithms to determine ad placement and marketing budgets.

While Google currently uses AI to generate basic ad copy, this new generative AI technology could help create more intricate ads that resemble those produced by marketing agencies. With the help of this technology, advertisers may be able to provide creative content like videos, images, and text tailored to specific campaigns.

Advertisers will also be able to supply “creative” content such as imagery, video, and text related to a specific campaign. Aside from incorporating generative AI into its advertising business, Google is reportedly developing a new search engine that uses AI to provide a more personalized experience for its users. Big company Google is now at a low level to use.

Additionally, the tech giant is also working on new AI features for its existing search engine, which is currently being developed under the codename “Magi.”

Elon Musk removes all legacy Blue ticks, allows some celebrities to retain

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Chaos prevailed on Twitter on Friday when Elon Musk finally removed all legacy verified accounts with Blue check marks but allowed some celebrities to retain them.

In India, one has to shell out Rs 900 a month (or Rs 9,400 a year) to get Blue Verified status.

As more than 4 lakh legacy verified users bid goodbye to the Blue check marks, some celebrities have been offered a complimentary Twitter Blue subscription “on behalf of Musk”.

“I am paying for a few personally,” said Musk. “Just William Shatner, LeBron James, and Stephen King,” he added.

Stephen King tweeted: “My Twitter account says I’ve subscribed to Twitter Blue. I haven’t. My Twitter account says I’ve given a phone number. I haven’t”.

Musk replied: “You’re welcome namaste.”

The Pope got downgraded along with Beyonce, Kim Kardashian, and Oprah Winfrey.

Rihanna and Taylor Swift still had Blue ticks but it was not sure if they bought them or if Musk allowed those to remain.

“Me joining you all tomorrow unverified,” tweeted actress Halle Berry, indicating she is not going to pay Musk for the Blue badge.

Many other NBA players, like Stephen Curry, Zion Williamson, and Ja Morant also lost their blue checks.

SpaceX’s giant Starship rocket explodes after launch

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SpaceX’s giant Starship rocket exploded after its launch from the US state of Texas on Thursday. The rocket got off the launch pad in SpaceX’s Starbase in South Texas but exploded minutes later. The spacecraft failed to reach orbit.

The launch was the first test flight of SpaceX’s fully integrated Starship and Super Heavy rocket, Xinhua news agency reported.

Starship experienced a rapid unscheduled disassembly before stage separation, according to SpaceX.

“Today’s test will help us improve Starship’s reliability as SpaceX seeks to make life multi-planetary,” the company tweeted.

Teams will continue to review data and work toward the next flight test, said SpaceX.

“Learnt a lot for next test launch in a few months,” Elon Musk, founder, CEO, and Chief Engineer of SpaceX, tweeted.

NASA Administrator Bill Nelson said that the launch of SpaceX’s Starship rocket is “a good first step”.

“It looks like they got through the first stage of this big monster rocket. That’s a real accomplishment. We’ll get a report on what happened to the second stage, but I’m very encouraged that they’ve gotten along this far,” Nelson told Media.

It was the second launch attempt of Starship after the first attempt was scrapped on Monday owing to technical issues.

A ‘mini-heart’ has been developed by German scientists.

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‘mini-heart’ known as organoid

A ‘mini-heart’ has been developed by German scientists, that is just 0.5 millimeters in size to study the earliest development phase of the human heart and facilitate research on diseases. The team from the Technical University of Munich (TUM) are the first researchers in the world to successfully create the ‘mini-heart’ known as organoid — containing both heart muscle cells (cardiomyocytes) and cells of the outer layer of the heart wall (epicardium).Although these do not pump blood, they can be stimulated electrically and are capable of contracting like human heart chambers. In the young history of heart organoids — the first were described in 2021 — researchers had previously created only organoids with cardiomyocytes and cells from the inner layer of the heart wall (endocardium).
Led by Alessandra Moretti, Professor of Regenerative Medicine in Cardiovascular Disease, the team developed a method for making a sort of ‘mini-heart’ using pluripotent stem cells. Around 35,000 cells are spun into a sphere in a centrifuge.

Over a period of several weeks, different signaling molecules are added to the cell culture under a fixed protocol. “In this way, we mimic the signaling pathways in the body that control the developmental programmed for the heart,” said Moretti. The team published their work in the journal Nature Biotechnology with an accompanying study published in Nature Communications. Through the analysis of individual cells the team determined that precursor cells of a type only recently discovered in mice are formed around the seventh day of the development of the organoid. “We assume that these cells also exist in the human body — if only for a few days,” said Moretti. These insights may also offer clues as to why the foetal heart can repair itself, a capability almost entirely absent in the heart of an adult human.

This knowledge could help to find new treatment methods for heart attacks and other conditions. Further, the team also showed that the organoids can be used to investigate the illnesses of individual patients. Using pluripotent stem cells from a patient suffering from Noonan syndrome — a genetic disorder that prevents normal development in various parts of the body, the researchers produced organoids that emulated characteristics of the condition in a Petri dish. Over the coming months the team plans to use comparable personalized organoids to investigate other congenital heart defects. With the possibility of emulating heart conditions in organoids, drugs could be tested directly on them in the future. “It is conceivable that such tests could reduce the need for animal experiments when developing drugs,” Moretti said.

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